Those who are united to Christ and effectually called and regenerated have a new heart and a new spirit created in them through the power of Christ’s death and resurrection. They are also further sanctified, really and personally (Ac 20:32; Ro 6:5-6), through the same power, by his Word and Spirit dwelling in them (Jn 17:17; Eph 3:16-19; 1Th 5:21-23). The dominion of the whole body of sin is destroyed (Ro 6:14), and the various evil desires that arise from it are more and more weakened and put to death (Gal 5:24). At the same time, those called and regenerated are more and more enlivened and strengthened in all saving graces (Col 1:11) so that they practice true holiness, without which no one will see the Lord (2Co 7:1; Heb 12:14).
This sanctification extends throughout the whole person (1Th 5:23), though it is never completed in this life. Some corruption remains in every part (Ro 7:18, 23). From this arises a continual and irreconcilable war, with the desires of the flesh against the Spirit and the Spirit against the flesh (Gal 5:17; 1Pe 2:11).
In this war, the remaining corruption may greatly prevail for a time (Ro 7:23). Yet through the continual supply of strength from the sanctifying Spirit of Christ, the regenerate part overcomes (Ro 6:14). So the saints grow in grace, perfecting holiness in the fear of God. They pursue a heavenly life, in gospel obedience to all the commands that Christ as Head and King has given them in his Word (Eph 4:14-16; 2Co 3:18; 7:1).